Atividade física e longevidade

Autores

  • Caroline Kitayama Prospektar Consultoria Científica e Tecnológica

DOI:

https://doi.org/10.61695/rcs.v1i1.11

Palavras-chave:

Atividade física, Envelhecimento, Longevidade, Metabolismo, Alterações hormonais, Independência

Resumo

O envelhecimento está relacionado a várias alterações orgânicas de um corpo. Há limitações físicas, com redução de habilidades, alteração de percepções, mudança nos reflexos. Os recursos medicamentosos têm como objetivo melhorar o funcionamento fisiológico do corpo, aumentando, ou oferecendo melhores condições para a manutenção de determinadas funções. No entanto, é importante observar as necessidades de independência e de autonomia dessa população. Entre as ações que devem ser aliadas a uma melhor adaptação a essa nova etapa da vida, a atividade física deve ser tratada como recurso indispensável para um envelhecimento ativo. Este estudo apresenta uma revisão da literatura ressaltando os apectos neuroanatomicos, neuro-humorais e a atividade física como regulador hormonal.

Downloads

Não há dados estatísticos.

Biografia do Autor

Caroline Kitayama, Prospektar Consultoria Científica e Tecnológica

Prospektar Consultoria Científica e Tecnológica, Brasília, DF.

Referências

Abdalla SM, Bianco AC. Defending plasma T3 is a biological priority. Clin Endocrinol (Oxf). 2014 Nov;81(5):633-41, 2014. https://doi.org/10.1111/cen.12538. PMID: 25040645.

Adam TC, Epel ES. Stress, eating and the reward system. Physiol Behav. 2007 Jul 24;91(4):449-58. https://doi.org/10.1016/j.physbeh.2007.04.011. PMID: 17543357.

Adeva-Andany MM, Funcasta-Calderón R, Fernández-Fernández C, Castro-Quintela E, Carneiro-Freire N. Metabolic effects of glucagon in humans. J Clin Transl Endocrinol. 2018 Dec 20;15:45-53. https://doi.org/10.1016/j.jcte.2018.12.005. PMID: 30619718.

Aguilera G, Liu Y. The molecular physiology of CRH neurons. Front Neuroendocrinol. 2012;33(1):67-84. https://doi.org/10.1016/j.yfrne.2011.08.002

Altaye KZ, Mondal S, Legesse K, Abdulkedir M. Effects of aerobic exercise on thyroid hormonal change responses among adolescents with intellectual disabilities. BMJ Open Sport Exerc Med. 2019 Jul 23;5(1):e000524. https://doi.org/10.1136/bmjsem-2019-000524. PMID: 31423321.

Andrews RC, Walker BR. Glucocorticoids and insulin resistance: old hormones, new targets. Clin Sci (Lond). 1999 May;96(5):513-23. https://doi.org/10.1042/cs0960513. PMID: 10209084.

Anyanwu, EC. Neurochemical changes in the aging process: implications in medication in the elderly. The Scientific World Journal. 2007 Feb;7:1603-10. https://doi.org/10.1100/tsw.2007.112

Arkader R, Rosa MR, Moretti G. Physiological changes of exercise of thermogenesis, thyroid homeostasis and inflammation. Endocrinol Metab Int J. 2016;3(4):85-8. https://doi.org/10.15406/emij.2016.03.00055

Arrojo E, Drigo R, Fonseca TL, Werneck-De-Castro JP, Bianco AC. Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochim Biophys Acta. 2013;1830(7):3956-64. https://doi.org/10.1016/j.bbagen.2012.08.019

Axelband F, Dias J, Ferrão FM, Einicker-Lamas M. Nongenomic signaling pathways triggered by thyroid hormones and their metabolite 3-iodothyronamine on the cardiovascular system. J Cell Physiol. 2011 Jan;226(1):21-8. https://doi.org/10.1002/jcp.22325

Baid S, Nieman LK. Glucocorticoid excess and hypertension. Curr Hypertens Rep. 2004 Dec;6(6):493-9. https://doi.org/10.1007/s11906-004-0046-0. PMID: 15527696.

Bailes J, Soloviev M. Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports. Biomolecules. 2021 Feb 4;11(2):217. https://doi.org/10.3390/biom11020217. PMID: 33557137.

Barbosa KBF, Costa NMB, Alfenas RCG, De Paula SO, Minim VPR, Bressan J. Estresse oxidativo: conceito, implicações e fatores modulatórios. Rev. Nutr. 2010 Ago;23(4):629-43 https://doi.org/10.1590/S1415-52732010000400013

Barceló P, Nicolau C, Gamundí A, Fiol MA, Tresguerres JA, Akaârir M, Rial RV. Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats. Oxid Med Cell Longev. 2016;2016:5863402. https://doi.org/10.1155/2016/5863402. Epub 2016 Dec 5. PMID: 28050228; PMCID: PMC5165162.

Bartke A. Growth Hormone and Aging: Updated Review. World J Mens Health. 2019 Jan;37(1):19-30. https://doi.org/10.5534/wjmh.180018. Epub 2018 May 11. PMID: 29756419; PMCID: PMC630586

Baskin KK, Winders BR, Olson EN. Muscle as a "mediator" of systemic metabolism. Cell Metab. 2015 Feb 3;21(2):237-248. https://doi.org/10.1016/j.cmet.2014.12.021. PMID: 25651178; PMCID: PMC4398026.

Batinic-Haberle I, Benov LT. An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation. Free Radical Research. 2008; 42(7):618–624. https://doi.org/10.1080/10715760802209639

Beaupere C, Liboz A, Fève B, Blondeau B, Guillemain G. Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance. International Journal of Molecular Sciences. 2021; 22(2):623. https://doi.org/10.3390/ijms22020623

Bianchi VE, Locatelli V, Rizzi L. Neurotrophic and Neuroregenerative Effects of GH/IGF1. Int J Mol Sci. 2017 Nov 17;18(11):2441. https://doi.org/10.3390/ijms18112441. PMID: 29149058; PMCID: PMC5713408.

Bianco AC, Da Conceição RR. The Deiodinase Trio and Thyroid Hormone Signaling. Methods Mol Biol. 2018;1801:67-83. https://doi.org/10.1007/978-1-4939-7902-8_8. PMID: 29892818; PMCID: PMC6668716.

Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002 Feb;23(1):38-89. https://doi.org/10.1210/edrv.23.1.0455. PMID: 11844744.

Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008 Feb;29(1):76-131. https://doi.org/10.1210/er.2006-0043. Epub 2007 Nov 8. PMID: 17991805.

Boucsein A, Kamstra K, Tups A. Central signalling cross‐talk between insulin and leptin in glucose and energy homeostasis. Journal of Neuroendocrinology. 2021;33(4). https://doi.org/10.1111/jne.12944

Bradshaw PC. Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging. Nutrients. 2019 Feb 27;11(3):504. https://doi.org/10.3390/nu11030504. PMID: 30818813; PMCID: PMC6471790.

Brito De Sá RM, Motta LB, Oliveira FJ. Insônia: prevalência e fatores de risco relacionados em população de idosos acompanhados em ambulatório. Rev. bras. geriatr. gerontol. 2007;10(2):217-30. https://doi.org/10.1590/1809-9823.2007.10027.

Bruce RM. The control of ventilation during exercise: a lesson in critical thinking. Adv Physiol Educ. 2017 Dec 1;41(4):539-547. https://doi.org/10.1152/advan.00086.2017. PMID: 29066604.

Burlá C, Camarano AA, Kanso S, Fernandes D, Nunes R. Panorama prospectivo das demências no Brasil: um enfoque demográfico. Ciênc. saúde coletiva. 2013 Out;18(10):2949-56 https://doi.org/10.1590/S1413-81232013001000019

Calsolaro V, Niccolai F, Pasqualetti G, Tognini S, Magno S, Riccioni T, Bottari M, Caraccio N, Monzani F. Hypothyroidism in the Elderly: Who Should Be Treated and How? Journal of the Endocrine Society. 2019 Jan;3(1):146–58. https://doi.org/10.1210/js.2018-00207

Campos-Barros A, Amma LL, Faris JS, Shailam R, Kelley MW, Forrest D. Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing. Proc Natl Acad Sci U S A . 2000 Feb 1;97(3):1287-92. https://doi.org/10.1073/pnas.97.3.1287. PMID: 10655523; PMCID: PMC15599.

Caprio S, Napoli R, Saccà L, Tamborlane WV, Sherwin RS. Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects. J Clin Endocrinol Metab. 1992 Oct;75(4):1076-80. https://doi.org/10.1210/jcem.75.4.1400874. PMID: 1400874

Cay M, Ucar C, Senol D, Cevirgen F, Ozbag D, Altay Z, et al. Effect of increase in cortisol level due to stress in healthy young individuals on dynamic and static balance scores. North Clin Istanb 2018;5(4):295–301. https://doi.org/10.14744/nci.2017.42103

Chan S, Debono M. Replication of cortisol circadian rhythm: new advances in hydrocortisone replacement therapy. Ther Adv Endocrinol Metab. 2010 Jun;1(3):129-38. https://doi.org/10.1177/2042018810380214. PMID: 23148157; PMCID: PMC3475279.

Chaouloff F, Laude D, Elghozi JL. Physical exercise: evidence for differential consequences of tryptophan on 5-HT synthesis and metabolism in central serotonergic cell bodies and terminals. J Neural Transm. 1989;78(2):121-30. https://doi.org/10.1007/BF01252498. PMID: 2478662.

Chen D, Zhang T, Lee TH. Cellular mechanisms of melatonin: insight from neurodegenerative diseases. Biomolecules. 2020; 10(8):1158. https://doi.org/10.3390/biom10081158

Chentli F, Azzoug S, Mahgoun S. Diabetes mellitus in elderly. Indian J Endocrinol Metab. 2015 Nov-Dec;19(6):744-52. https://doi.org/10.4103/2230-8210.167553. PMID: 26693423; PMCID: PMC4673801.

Cho ES, Cha YH, Kim HS, Kim NH, Yook JI. The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy. Biomol Ther (Seoul). 2018 Jan 1;26(1):29-38. https://doi.org/10.4062/biomolther.2017.179. PMID: 29212304; PMCID: PMC5746035.

Coderre L, Vallega GA, Pilch PF, Chipkin SR. In vivo effects of dexamethasone and sucrose on glucose transport (GLUT-4) protein tissue distribution. American Journal of Physiology-Endocrinology and Metabolism.1996; 271(4), E643–E648. https://doi.org/10.1152/ajpendo.1996.271.4.E643

Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E, Rabin BS, Turner RB. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5995-9. https://doi.org/10.1073/pnas.1118355109. Epub 2012 Apr 2. PMID: 22474371; PMCID: PMC3341031.

Conboy IM, Rando TA. Aging, stem cells and tissue regeneration: lessons from muscle. Cell Cycle. 2005 Mar;4(3):407-10. https://doi.org/10.4161/cc.4.3.1518. Epub 2005 Mar 7. PMID: 15725724.

Cruzat VF, Donato Júnior J, Tirapegui J, Schneider CD. Hormônio do crescimento e exercício físico: considerações atuais. Revista Brasileira De Ciências Farmacêuticas. 2008;44(4):549-62. https://doi.org/10.1590/S1516-93322008000400003

Cuenoud B, Ipek Ö, Shevlyakova M, Beaumont M, Cunnane SC, Gruetter R, Xin L. Brain Nad Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans. Front Aging Neurosci. 2020 Dec 16;12:609517. https://doi.org/10.3389/fnagi.2020.609517. PMID: 33390929; PMCID: PMC7772416.

D'alonzo M, Bounous VE, Villa M, Biglia N. Current evidence of the oncological benefit-risk profile of hormone replacement therapy. Medicina (Kaunas). 2019 Sep 7;55(9):573. https://doi.org/10.3390/medicina55090573. PMID: 31500261; PMCID: PMC6780494.

Davis PJ, Goglia F, Leonard JL. Nongenomic actions of thyroid hormone. Nat Rev Endocrinol. 2016 Feb;12(2):111-21. https://doi.org/10.1038/nrendo.2015.205. Epub 2015 Dec 15. PMID: 26668118.

Davis PJ, Mousa SA, Lin HY. Nongenomic Actions of Thyroid Hormone: The Integrin Component. Physiol Rev. 2021 Jan 1;101(1):319-352. https://doi.org/10.1152/physrev.00038.2019. Epub 2020 Jun 25. Erratum in: Physiol Rev. 2023 Jan 1;103(1):607. PMID: 32584192.

De Guia RM, Agerholm M, Nielsen, TS, Consitt LA, Søgaard D, Helge JW, Larsen S, Brandauer J, Houmard JA, Treebak JT. Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle. Physiol Rep. 2019 Jul;7(12):e14139. https://doi.org/10.14814/phy2.14139. PMID: 31207144; PMCID: PMC6577427.

De Mello AAF, De Mello MF, Carpenter, LL, Price LH. Update on stress and depression: the role of the hypothalamic-pituitary adrenal (HPA) axis. Revista Brasileira de Psiquiatria. 2003 Oct;5(4):231-8. https://doi.org/10.1590/S1516-44462003000400010

De Rezende Gomes M, Santana De Oliveira Pires I, Alves De Castro I, Tirapegui J. Effect of moderate physical exercise on plasma and tissue levels of insulin-like growth factor–1 in adult rats. Nutrition Research; 2004;24(7), 555–564. https://doi.org/10.1016/j.nutres.2004.04.003

De Souza KA, Freitas FFQ, Castro AP, Oliveira CDB, De Almeida AAB, Souza KA. Prevalência de sintomas de depressão em idosos assistidos pela estratégia de saúde da família. Rev. Min. Enferm. 2017;21(e1018):1-7.

Del Rincon JP, Iida K Gaylinn BD, Mccurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO. Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance. Diabetes. 2007 Jun;56(6):1638-46. https://doi.org/10.2337/db06-0299. Epub 2007 Mar 15. PMID: 17363744.

Donahue CP, Kosik KS, Shors TJ. Growth hormone is produced within the hippocampus where it responds to age, sex, and stress. Proceedings of the National Academy of Sciences. 2006 Apr;103 (15):6031-6. https://doi.org/10.1073/pnas.0507776103

Donangelo I, Suh SY. Subclinical Hyperthyroidism: When to Consider Treatment? Allegheny Health Network, Pittsburgh, Pennsylvania Am Fam Physician [Internet]. 2017 Jun 1;95(11):710-6. Disponível em: https://www.aafp.org/afp/2017/0601/p710.html

Fekete C, Lechan RM. Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase. Front Neuroendocrinol. 2007 Aug-Sep;28(2-3):97-114. https://doi.org/10.1016/j.yfrne.2007.04.002. Epub 2007 May 21. PMID: 17588648; PMCID: PMC2000455.

Ferraù F, Albani A, Ciresi A, Giordano C, Cannavò S. Diabetes Secondary to Acromegaly: Physiopathology, Clinical Features and Effects of Treatment. Front Endocrinol (Lausanne). 2018 Jul 6;9:358. https://doi.org/10.3389/fendo.2018.00358. PMID: 30034367; PMCID: PMC6043782.

Ferreira Mendes JM, De Faro Valverde L, Torres Andion Vidal M, Paredes BD, Coelho P, Allahdadi KJ, Coletta RD, Souza BSDF, Rocha CAG. Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences. 2020; 21(18):6487. https://doi.org/10.3390/ijms21186487

Ferris HA, Kahn CR. New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it. J Clin Invest. 2012 Nov;122(11):3854-7. https://doi.org/10.1172/JCI66180. Epub 2012 Oct 24. PMID: 23093783; PMCID: PMC3484465

Flier JS, Harris M, Hollenberg AN. Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring. J Clin Invest. 2000;105(7):859-61. https://doi.org/10.1172/JCI9725

Fujikawa T. Central regulation of glucose metabolism in an insulin‐dependent and ‐independent manner. Journal of Neuroendocrinology. 2021;33(4). https://doi.org/10.1111/jne.12941

Funder JW. Mineralocorticoid receptors: distribution and activation. Heart Fail Rev. 2005 Jan;10(1):15-22. https://doi.org/10.1007/s10741-005-2344-2. PMID: 15947887.

Gallis JL, Gin H, Roumes H. et al. A metabolic link between mitochondrial ATP synthesis and liver glycogen metabolism: NMR study in rats re-fed with butyrate and/or glucose. Nutr Metab (Lond) 8, 38 (2011). https://doi.org/10.1186/1743-7075-8-38

Gasperi M, Castellano AE. Growth hormone/insulin-like growth factor I axis in neurodegenerative diseases. Journal of Endocrinological Investigation. 2010;33(8), 587–591. https://doi.org/10.1007/BF03346653

Ge Tongxin, Yang Jiawen, Zhou Shihui, Wang Yuchen, Li Yakui, Tong Xuemei. The Role of the Pentose Phosphate Pathway in Diabetes and Cancer. Frontiers in Endocrinology. 2020;11(365):365 https://doi.org/10.3389/fendo.2020.00365.

Geer EB, Islam J, Buettner C. Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism. Endocrinol Metab Clin North Am. 2014 Mar;43(1):75-102. https://doi.org/10.1016/j.ecl.2013.10.005. PMID: 24582093; PMCID: PMC3942672.

George SA, Khan S, Briggs H, Abelson, JL. CRH-stimulated cortisol release and food intake in healthy, non-obese adults. Psychoneuroendocrinology. 2010 May;35(4):607-12. https://doi.org/10.1016/j.psyneuen.2009.09.017. Epub 2009 Oct 13. PMID: 19828258; PMCID: PMC2843773.

Gesing A. The thyroid gland and the process of aging. Thyroid Res. 2015;8(Suppl 1):A8. Published 2015 Jun 22. https://doi.org/10.1186/1756-6614-8-S1-A8

Glancy B, Balaban RS. Protein composition and function of red and white skeletal muscle mitochondria. Am J Physiol Cell Physiol. 2011;300(6):C1280-C1290. https://doi.org/10.1152/ajpcell.00496.2010

Gomez-Sanchez E, Gomez-Sanchez CE. The multifaceted mineralocorticoid receptor. Compr Physiol. 2014 Jul;4(3):965-94. https://doi.org/10.1002/cphy.c130044. PMID: 24944027; PMCID: PMC4521600.

Gouarné C, Groussard C, Gratas-Delamarche A, Delamarche P, Duclos M. Overnight urinary cortisol and cortisone add new insights into adaptation to training. Med Sci Sports Exerc. 2005 Jul;37(7):1157-67. https://doi.org/10.1249/01.mss.0000170099.10038.3b

Guadaño-Ferraz A, Escámez MJ, Rausell E, Bernal J. Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems. J Neurosci. 1999 May 1;19(9):3430-9. https://doi.org/10.1523/JNEUROSCI.19-09-03430.1999. PMID: 10212303; PMCID: PMC6782260.

Heijnen S, Hommel B, Kibele A, Colzato LS. Neuromodulation of Aerobic Exercise - A Review. Front Psychol. 2016 Jan 7;6:1890. https://doi.org/10.3389/fpsyg.2015.01890. PMID: 26779053; PMCID: PMC4703784.

Hernandez A, Stohn JP. The Type 3 Deiodinase: Epigenetic Control of Brain Thyroid Hormone Action and Neurological Function. Int J Mol Sci. 2018 Jun 19;19(6):1804. https://doi.org/10.3390/ijms19061804. PMID: 29921775; PMCID: PMC6032375.

Hill EE, Zack E, Battaglini C, Viru M, Viru A, Hackney AC. Exercise and circulating cortisol levels: the intensity threshold effect. J. Endocrinol Invest. 2008 Jul;31(7):587-91. https://doi.org/10.1007/BF03345606. PMID: 18787373.

Hirotsu C, Tufik S, Andersen ML. Interactions between sleep, stress, and metabolism: From physiological to pathological conditions. Sleep Sci. 2015 Nov;8(3):143-52. https://doi.org/10.1016/j.slsci.2015.09.002. Epub 2015 Sep 28. PMID: 26779321; PMCID: PMC4688585.

Hsuchou H, Wang Y, Cornelissen-Guillaume GG, Kastin AJ, Jang E, Halberg F, Pan W. Diminished leptin signaling can alter circadian rhythm of metabolic activity and feeding. J Appl Physiol (1985). 2013 Oct 1;115(7):995-1003. https://doi.org/10.1152/japplphysiol.00630.2013. Epub 2013 Jul 18. PMID: 23869060; PMCID: PMC3798820.

Huang SA. Physiology and pathophysiology of type 3 deiodinase in humans. Thyroid. 2005 Aug;15(8):875-81. https://doi.org/10.1089/thy.2005.15.875. PMID: 16131330.

Iwen KA, Oelkrug R, Brabant G. Effects of thyroid hormones on thermogenesis and energy partitioning. Journal of Molecular Endocrinology. 2018;60(3), R157–R170. https://doi.org/10.1530/JME-17-0319

Jeon YK, Ha CH. Expression of brain-derived neurotrophic factor, IGF-1 and cortisol elicited by regular aerobic exercise in adolescents. J Phys Ther Sci. 2015 Mar;27(3):737-41. https://doi.org/10.1589/jpts.27.737. Epub 2015 Mar 31. PMID: 25931720; PMCID: PMC4395704.

Jéquier E. Leptin signaling, adiposity, and energy balance. Ann N Y Acad Sci. 2002 Jun;967:379-88. https://doi.org/10.1111/j.1749-6632.2002.tb04293.x. PMID: 12079865.

Johnson S, Imai SI. Nad + biosynthesis, aging, and disease. F1000Res. 2018 Feb 1;7:132. https://doi.org/10.12688/f1000research.12120.1. PMID: 29744033; PMCID: PMC5795269.

Kargl C, Arshad M, Salman F, Schurman RC, Del Corral P. 11β-hydroxysteroid dehydrogenase type-II activity is affected by grapefruit juice and intense muscular work. Arch Endocrinol Metab. 2017 Dec;61(6):556-61. https://doi.org/10.1590/2359-3997000000296. Epub 2017 Sep 18. PMID: 28977167.

Khani S, Tayek JA. Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome. Clin Sci (Lond) . 2001 Dec;101(6):739-47. https://doi.org/10.1042/cs1010739. PMID: 11724664.

Kim SH, Park MJ. Effects of growth hormone on glucose metabolism and insulin resistance in human. Ann Pediatr Endocrinol Metab. 2017 Sep;22(3):145-152. https://doi.org/10.6065/apem.2017.22.3.145. Epub 2017 Sep 28. PMID: 29025199; PMCID: PMC5642081.

Koning ACAM, Buurstede JC, Van Weert LTCM, Meijer OC. Glucocorticoid and Mineralocorticoid Receptors in the Brain: A Transcriptional Perspective. J Endocr Soc. 2019 Jul 24;3(10):1917-1930. https://doi.org/10.1210/js.2019-00158. PMID: 31598572; PMCID: PMC6777400.

Kuo JZ, Guo X, Klein R, Klein BE, Genter P, Roll K, Hai Y, Goodarzi MO, Rotter JI, Chen YD, Ipp E. Adiponectin, Insulin Sensitivity and Diabetic Retinopathy in Latinos with Type 2 Diabetes. J Clin Endocrinol Metab. 2015 Sep;100(9):3348-55. https://doi.org/10.1210/jc.2015-1221. Epub 2015 May 28. PMID: 26020763; PMCID: PMC4570164.

Lambillotte C, Gilon P, Henquin JC. An in vitro study of dexamethasone effects in mouse islets. J Clin Invest. 1997;99(3):414–423. https://doi.org/10.1172/JCI119175

Lapierre MP, Abraham MA. Filippi BM. et al. Glucagon and lipid signaling in the hypothalamus. Mamm Genome. 2014;25:434–41. https://doi.org/10.1007/s00335-014-9510-6

Larsen PR. Type 2 iodothyronine deiodinase in human skeletal muscle: new insights into its physiological role and regulation. J Clin Endocrinol Metab. 2009 Jun;94(6):1893-5. https://doi.org/10.1210/jc.2009-0791. PMID: 19494166; PMCID: PMC2690423.

Lecavalier L, Bolli G, Cryer P, Gerich J. Contribution of gluconeogenesis and glycogenolysis during glucose counterregulation in normal humans. Am. J. Physiol. 1989;256, E844–E851. https://doi.org/10.1152/ajpendo.1989.256.6.E844

Lechan RM, Fekete C. Role of thyroid hormone deiodination in the hypothalamus. Thyroid. 2005 Aug;15(8):883-97. https://doi.org/10.1089/thy.2005.15.883. PMID: 16131331.

Lechan R, Fekete CSABA. The TRH neuron: a hypothalamic integrator of metabolism. Progress in brain research. 2006;153:209-35. https://doi.org/10.1016/S0079-6123(06)53012-2.

Leite-Cavalcanti C, Rodrigues-Gonçalves MC, Rios-Asciutti LS, Leite-Cavalcanti A. Prevalência de doenças crônicas e estado nutricional em um grupo de idosos brasileiros. Rev. salud pública [Internet]. 2009;11(6):865-77. https://doi.org/10.1590/S0124-00642009000600003

Lima-Silva AE, Fernandes TC, De-Oliveira FR, Nakamura FY, Gevaerd M Da S. Metabolismo do glicogênio muscular durante o exercício físico: mecanismos de regulação. Revista de Nutrição. 2007;20(4), 417–429. https://doi.org/10.1590/S1415-52732007000400009

Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferreira R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. Increased demand for NAD+ relative to ATP drives aerobic glycolysis. Mol Cell. 2021 Feb 18;81(4):691-707.e6. https://doi.org/10.1016/j.molcel.2020.12.012. Epub 2020 Dec 30. PMID: 33382985; PMCID: PMC8315838.

Luongo C, Martin C, Vella K, Marsili A, Ambrosio R, Dentice M, Harney JW, Salvatore D, Zavacki AM, Larsen, PR. The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism. Endocrinology. 2015 Feb;156(2):745-54. https://doi.org/10.1210/en.2014-1698. Epub 2014 Dec 2. PMID: 25456070; PMCID: PMC4298316.

Macfarlane DP, Forbes S, Walker BR. Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome. J Endocrinol. 2008 May;197(2):189-204. https://doi.org/10.1677/JOE-08-0054. PMID: 18434349.

Machado MB, Ignácio ZM, Jornada LK, Réus GZ, Abelaira HM, Arent CO, Schwalm MT, Ceretta RA, Ceretta LB, Quevedo J. Prevalência de transtornos ansiosos e algumas comorbidades em idosos: um estudo de base populacional. J. bras. psiquiatr. 2019;65(1):28-35. https://doi.org/10.1590/0047-2085000000100

Maia AL, Kim BW, Huang SA, Harney JW, Larsen PR. Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest. 2005 Sep;115(9):2524-33. https://doi.org/10.1172/JCI25083. Epub 2005 Aug 25. PMID: 16127464; PMCID: PMC1190373.

Maia AL, Goemann IM, Meyer ELS, Wajner SM. (2011). Type 1 iodothyronine deiodinase in human physiology and disease. Journal of Endocrinology.2001; 209(3):283–297. https://doi.org/10.1530/JOE-10-0481

Mangos GJ, Walker BR, Kelly JJ, Lawson JA, Webb DJ, Whitworth JA. Cortisol inhibits cholinergic vasodilation in the human forearm. Am J Hypertens. 2000 Nov;13(11):1155-60. https://doi.org/10.1016/S0895-7061(00)01201-2. PMID: 11078174.

Manson JE, Chlebowski RT, Stefanick M L, Aragaki AK, Rossouw JE, Prentice RL, Anderson G, Howard BV, Thomson CA, Lacroix AZ, Wactawski-Wende J, Jackson RD, Limacher M, Margolis KL, Wassertheil-Smoller S, Beresford SA, Cauley JA, Eaton CB, Gass M, Hsia J, Johnson KC, Kooperberg C, Kuller LH, Lewis CE, Liu S, Martin LW, Ockene J K, O'sullivan MJ, Powell LH, Simon MS, Van Horn L, Vitolins MZ, Wallace, RB. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. JAMA. 2013 Oct 2;310(13):1353-68. https://doi.org/10.1001/jama.2013.278040. PMID: 24084921; PMCID: PMC3963523.

Moore JS, Monson JP, Kaltsas G, Putignano P, Wood PJ, Sheppard MC, Besser GM, Taylor NF, Stewart PM. Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by growth hormone and insulin-like growth factor: in vivo and in vitro studies. J Clin Endocrinol Metab. 1999 Nov;84(11):4172-7. https://doi.org/10.1210/jcem.84.11.6108. PMID: 10566668.

Moreno CRC, Santos JLF, Lebrão ML, Ulhôa MA, Duarte YA. O. Problemas de sono em idosos estão associados a sexo feminino, dor e incontinência urinária. Rev. bras. epidemiol. 2019;21(Suppl 2):1-8. https://doi.org/10.1590/1980-549720180018.supl.2

Moretti T, Moretti MP, Moretti M, Sakae TM, Sakae DY, Araújo D. Estado nutricional e prevalência de dislipidemias em idosos. ACM arq. catarin. med. [Internet] 2009;38(3):12-6. Disponível em: http://www.acm.org.br/acm/revista/pdf/artigos/747.pdf

Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev. 2014 Apr;94(2):355-82. https://doi.org/10.1152/physrev.00030.2013. PMID: 24692351; PMCID: PMC4044302.

Møller N, Jørgensen JO. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev. 2009 Apr;30(2):152-77. https://doi.org/10.1210/er.2008-0027. Epub 2009 Feb 24. PMID: 19240267.

Narsimulu B, Qureshi R, Jakkula P, Are S, Qureshi IA. Biophysical and Structural Characterization of Ribulose-5-phosphate Epimerase from Leishmania donovani. ACS Omega. 2021 Dec 17;7(1):548-564. https://doi.org/10.1021/acsomega.1c04967. PMID: 35036723; PMCID: PMC8756792.

Nichols NR. Glucocorticoids and aging. Functional Endocrilonology of Aging. 1998;29:1-26. https://doi.org/10.1159/000061414.

Nyberg F, Hallberg M. Growth hormone and cognitive function. Nat Rev Endocrinol. 2013 Jun;9(6):357-65. https://doi.org/10.1038/nrendo.2013.78. Epub 2013 Apr 30. PMID: 23629538.

Okabe K, Yaku K, Tobe K. et al. Implications of altered NAD metabolism in metabolic disorders. J Biomed Sci. 2019; 26(34). https://doi.org/10.1186/s12929-019-0527-8

Paredes S, Ribeiro L. Cortisol: the villain in Metabolic Syndrome? Rev Assoc Med Bras. 2014 Jan-Fev;60(1):84-92 https://doi.org/10.1186/s12929-019-0527-8

Pataky MW, Young WF, Nair KS. Hormonal and metabolic changes of aging and the influence of lifestyle modifications. Thematic Review on Aging and Geriatric Medicine. 2021;96(3):788-814. https://doi.org/10.1590/1806-9282.60.01.017

Paulsen SK, Pedersen SB, Jørgensen JO, Fisker S, Christiansen JS, Flyvbjerg A, Richelsen B. Growth hormone (GH) substitution in GH-deficient patients inhibits 11beta-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression in adipose tissue. J Clin Endocrinol Metab. 2006 Mar;91(3):1093-8. https://doi.org/10.1016/j.mayocp.2020.07.033. Epub 2005 Dec 20. PMID: 16368752.

Payne JD, Nadel L. Sleep, dreams, and memory consolidation: the role of the stress hormone cortisol. Learn Mem. 2004 Nov-Dec;11(6):671-8. https://doi.org/10.1101/lm.77104. PMID: 15576884; PMCID: PMC534695.

Pimenta FB, Pinho L, Silveira MF, Botelho ACC. Fatores associados a doenças crônicas em idosos atendidos pela Estratégia de Saúde da Família. Ciênc. saúde coletiva. 2015;20(8):2489-98. https://doi.org/10.1590/1413-81232015208.11742014

Poidvin A, Weill A, Ecosse E, Coste J, Carel JC. Risk of diabetes treated in early adulthood after growth hormone treatment of short stature in childhood. J Clin Endocrinol Metab. 2017 Apr 1;102(4):1291-1298. https://doi.org/10.1210/jc.2016-3145. PMID: 28324032.

Pollak N, Dölle C, Ziegler M. The power to reduce: pyridine nucleotides--small molecules with a multitude of functions. Biochem J. 2007;402(2):205-18. https://doi.org/10.1042/BJ20061638

Ramadan W, Marsili A, Larsen PR, Zavacki AM, Silva JE. Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice. Endocrinology. 2011 Aug;152(8):3093-102. https://doi.org/10.1210/en.2011-0139. Epub 2011 Jun 7. PMID: 21652727; PMCID: PMC3138235.

Ranabir S, Reetu K. Stress and hormones. Indian journal of endocrinology and metabolism. 2011;15(1):18–22. https://doi.org/10.4103/2230-8210.77573. PMID: 21584161; PMCID: PMC3079864.

Rhodin A, Von Ehren M, Skottheim B, Grönbladh A, Ortiz‐Nieto F, Raininko R, Gordh T, And Nyberg F. GH improves cognition in pain patient. Acta Anaesthesiol Scand. 2014;58:759-65. https://doi.org/10.1111/aas.12309

Ribeiro L, Calhau C, Pinheiro-Silva S, Santos A, Alçada M, Guimarães J, Pina A, Maia B, Pereira F, Pimentel F, Lopes H, Santos L, Gonçalves N, Cunha S, Viana P, Almeida J, Lopes A, Azevedo I. Exercício físico e insulina, hormona do crescimento e somatostatina [Impact of acute exercise intensity on plasma concentrations of insulin, growth hormone and somatostatin]. Acta Med Port [Internet]. 2004 May-Jun;17(3):199-204. Portuguese. Epub 2004 Jun 30. PMID: 15929847. Disponível em: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/viewFile/1087/752

Rizza RA, Mandarino LJ, Gerich JE. Cortisol-Induced Insulin Resistance in Man: Impaired Suppression of Glucose Production and Stimulation of Glucose Utilization due to a Postreceptor Defect of Insulin Action. The Journal of Clinical Endocrinology & Metabolism. 1982;54(1):131–138. https://doi.org/10.1210/jcem-54-1-131

Robinson-Agramonte MLA, Michalski B, Vidal-Martinez B, Hernández LR, Santiesteban MW, Fahnestock M. BDNF, proBDNF and IGF-1 serum levels in naïve and medicated subjects with autism. Sci Rep. 2022 Aug 12;12(1):13768. https://doi.org/10.1038/s41598-022-17503-6. PMID: 35962006; PMCID: PMC9374711.

Roemmich JN, Rogol AD. Exercise and growth hormone: does one affect the other? J Pediatr. 1997 Jul;131(1 Pt 2):S75-80. https://doi.org/10.1016/S0022-3476(97)70017-9. PMID: 9255234.

Romaldini JH, Sgarbi JA, Farah CS. Disfunções mínimas da tiróide: hipotiroidismo subclínico e hipertiroidismo subclínico. Arquivos Brasileiros de Endocrinologia & Metabologia. 2004;48(1):147–58. https://doi.org/10.1590/S0004-27302004000100016

Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN, Walter MA. American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016 Oct;26(10):1343-1421. https://doi.org/10.1089/thy.2016.0229. Erratum in: Thyroid. 2017 Nov;27(11):1462. PMID: 27521067.

Russell-Aulet M, Dimaraki EV, Jaffe CA, Demott-Friberg R, Barkan AL. Aging-related growth hormone (GH) decrease is a selective hypothalamic GH-releasing hormone pulse amplitude mediated phenomenon. J Gerontol A Biol Sci Med Sci. 2001 Feb;56(2):M124-9. https://doi.org/10.1093/gerona/56.2.M124. PMID: 11213276.

Sabatino L, Vassalle C, Del Seppia C, Iervasi G. Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions. Endocrinol Metab (Seoul). 2021 Oct;36(5):952-964. https://doi.org/10.3803/EnM.2021.1198. Epub 2021 Oct 21. PMID: 34674502; PMCID: PMC8566136.

Santos Palacios S, Pascual-Corrales E, Galofre JC. Management of Subclinical Hyperthyroidism. Int J Endocrinol Metab. 2012;10(2):490-6. https://doi.org/10.5812/ijem.3447

Satoh A, Imai SI, Guarente L. The brain, sirtuins, and ageing. Nat Rev Neurosci. 2017;18:362–74. https://doi.org/10.1038/nrn.2017.42

Sharma R, Kopchick JJ, Puri V, Sharma VM. Effect of growth hormone on insulin signaling. Mol Cell Endocrinol. 2020 Dec 1;518:111038. https://doi.org/10.1016/j.mce.2020.111038. Epub 2020 Sep 20. PMID: 32966863; PMCID: PMC7606590.

Silva JE. Thyroid Hormone Control of Thermogenesis and Energy Balance. Thyroid. 1995;5(6):481–492. https://doi.org/10.1089/thy.1995.5.481

Slominski A. On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders. Br J Dermatol. 2009 Feb;160(2):229-32. https://doi.org/10.1111/j.1365-2133.2008.08958.x. PMID: 19187344; PMCID: PMC2649670.

Souza Meyer E, Wagner MS, Maia AL. Expressão das iodotironinas desiodases nas neoplasias tireoidianas. Arquivos Brasileiros de Endocrinologia & Metabologia (Sociedade Brasileira de Endocrinologia e Metabologia). 2007 July. https://doi.org/10.1590/S0004-27302007000500006

Spinola e Castro AM, Guerra-Júnior G. GH/IGF e neoplasia: o que há de novo nesta associação. Arquivos Brasileiros de Endocrinologia e Metabolismo. 2005 Out;49(5):833-42. https://doi.org/10.1590/S0004-27302005000500026

Stark R, Reichenbach A, Andrews ZB. Hypothalamic carnitine metabolism integrates nutrient and hormonal feedback to regulate energy homeostasis. Molecular and Cellular Endocrinology. 2015;418:9–16. https://doi.org/10.1016/j.mce.2015.08.002

Stimson RH, Andersson J, Andrew R, Redhead DN, Karpe F, Hayes PC, Olsson T, Walker BR. Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans. Diabetes. 2009 Jan;58(1):46-53. https://doi.org/10.2337/db08-0969. Epub 2008 Oct 13. PMID: 18852329; PMCID: PMC2606892.

Morgan SA, Berryman DE, List EO, Lavery GG, Stewart PM, Kopchick JJ. Regulation of 11β-HSD1 by GH/IGF-1 in key metabolic tissues may contribute to metabolic disease in GH deficient patients. Growth Horm IGF Res. 2022 Feb;62:101440. https://doi.org/10.1016/j.ghir.2021.101440. Epub 2021 Nov 17. PMID: 34814007.

Takano A, Haruta T, Iwata M, Usui I, Uno T, Kawahara J, Ueno E, Sasaoka T. Kobayashi, M. Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes. Diabetes. 2001 Aug;50(8):1891-900. https://doi.org/10.2337/diabetes.50.8.1891. PMID: 11473053.

TARAFDAR A, PULA G. The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders. Int J Mol Sci. 2018 Nov 30;19(12):3824. https://doi.org/10.3390/ijms19123824. PMID: 30513656; PMCID: PMC6321244.

Tavares DMS, Pelizaro PB, Pegorari MS, De Paiva MM, Marchiori GF. Prevalência de morbidades autorreferidas e fatores associados entre idosos comunitários de Uberaba, Minas Gerais, Brasil. Ciênc. saúde coletiva. 2019;24(9):3305-13. https://doi.org/10.1590/1413-81232018249.31912017

Valverde I, Penalva A, Dieguez C. Influence of different serotonin receptor subtypes on growth hormone secretion. Neuroendocrinology. 2000 Feb;71(2):145-53. https://doi.org/10.1159/000054530. PMID: 10686528.

Van Cauter E, Plat L, Leproult R, Copinschi G. Alterations of circadian rhythmicity and sleep in aging: endocrine consequences. Horm Res. 1998;49(3-4):147-52. https://doi.org/10.1159/000023162. PMID: 9550116.

Van Den Beld AW, Kaufman JM, Zillikens MC, Lamberts SWJ, Egan JM, Van Der Lely AJ. The physiology of endocrine systems with ageing. Lancet Diabetes Endocrinol. 2018 Aug;6(8):647-58. https://doi.org/10.1016/S2213-8587(18)30026-3. Epub 2018 Jul 17. PMID: 30017799; PMCID: PMC6089223.

Walser M, Svensson J, Karlsson L, Motalleb R, Åberg M, Kuhn HG, Isgaard J, Åberg ND. Growth Hormone and Neuronal Hemoglobin in the Brain—Roles in Neuroprotection and Neurodegenerative Diseases. Front. Endocrinol. 11:606089. https://doi.org/10.3389/fendo.2020.606089

Wasinski F, Frazão R, Donato J. Effects of growth hormone in the central nervous system. Archives of Endocrinology and Metabolism. 2019;63(6), 549–556. https://doi.org/10.20945/2359-3997000000184

Werneck De Castro JP, Fonseca TL, Ueta CB, Mcaninch EA, Abdalla S, Wittmann G, Lechan RM, Gereben B, Bianco AC. Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest. 2015 Feb;125(2):769-81. https://doi.org/10.1172/JCI77588. Epub 2015 Jan 2. PMID: 25555216; PMCID: PMC4319436.

Wideman L, Weltman JY, Hartman ML, Veldhuis JD, Weltman A. Growth hormone release during acute and chronic aerobic and resistance exercise: recent findings. Sports Med. 2002;32(15):987-1004. https://doi.org/10.2165/00007256-200232150-00003. PMID: 12457419.

Xie N, Zhang L, Gao W, Huang C, Huber PE, Zhou X, Li C, Shen G, Zou B. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther. 2020 Oct 7;5(1):227. https://doi.org/10.1038/s41392-020-00311-7. PMID: 33028824; PMCID: PMC7539288.

Yaku K, Okabe K, Nakagawa T. Nad metabolism: Implications in aging and longevity. Ageing Res Rev. 2018 Nov;47:1-17. https://doi.org/10.1016/j.arr.2018.05.006. Epub 2018 Jun 5. PMID: 29883761.

YAU, W. W., YEN, P. M. Thermogenesis in Adipose Tissue Activated by Thyroid Hormone. Int J Mol Sci. 2020 Apr 24;21(8):3020. https://doi.org/10.3390/ijms21083020. PMID: 32344721; PMCID: PMC7215895.

Yiallouris A, Tsioutis C, Agapidaki E, Zafeiri M, Agouridis AP, Ntourakis D, Johnson EO. Adrenal aging and its implications on stress responsiveness in humans. Frontiers in Endocrinology [Internet]. 2019;10:54. Disponível em: https://www.frontiersin.org/article/10.3389/fendo.2019.00054. https://doi.org/10.3389/fendo.2019.00054.

Zhao D, Yu Y, Shen Y, Liu Q, Zhao Z, Sharma R, Reiter RJ. Melatonin Synthesis and Function: Evolutionary History in Animals and Plants. Front Endocrinol (Lausanne). 2019 Apr 17;10:249. PMID: 31057485; PMCID: PMC6481276. https://doi.org/10.3389/fendo.2019.00249

Zierath JR, Hawley JA. Skeletal muscle fiber type: influence on contractile and metabolic properties. PLoS Biol. 2004 Oct;2(10):e348. https://doi.org/10.1371/journal.pbio.0020348. Epub 2004 Oct 12. PMID: 15486583; PMCID: PMC521732.

Downloads

Publicado

2023-10-25

Como Citar

Kitayama, C. (2023). Atividade física e longevidade. Revista Ciências Da Saúde Ceuma, 1(1), 116–141. https://doi.org/10.61695/rcs.v1i1.11

Edição

Seção

Artigos