O uso de biomarcadores de estresse oxidativo no estudo de exposição a agrotóxicos
uma revisão
DOI:
https://doi.org/10.61695/rcs.v1i1.2Palavras-chave:
Saúde Ocupacional, Agrotóxicos, Estrese oxidativo, Biomarcadores, BiomonitoramentoResumo
O uso extensivo de compostos químicos na agricultura tem sido relacionado com a exposição ocupacional de agricultores, além da degradação e contaminação ambiental. Tais fatores, podem potencializar o desequilíbrio entre os compostos oxidantes e antioxidantes, permitindo, assim, a produção excessiva de espécies reativas de oxigênio, o que pode causar danos às biomoléculas e originar diversas doenças, dentre elas o Alzheimer e o câncer. Para correlacionar os efeitos tóxicos à exposição aos agrotóxicos os biomarcadores de estresse oxidativo se tornaram alternativa viável, pois são moléculas mais estáveis, específicas e sensíveis, com maior capacidade de mensuração, podendo expressar processos biológicos normais e patológicos, ou respostas farmacológicas a intervenções terapêuticas. Assim, este trabalho teve como objetivo avaliar a aplicação do uso de biomarcadores de estresse oxidativo no estudo da exposição aos agrotóxicos. Após a revisão da literatura em bases de dados online (PubMed, Science Direct, Web of Science e Google Scholar), foi possível concluir que diferentes parâmetros têm sido usados como ferramentas fundamentais durante todas as etapas da avaliação de risco após a exposição a agrotóxicos.
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Referências
Basu N. et al. A State-of-the-Science Review of Mercury Biomarkers in Human Populations Worldwide between 2000 and 2018. Environmental health perspectives. 2018; 126(10):106001. https://doi.org/10.1289/EHP3904
Beedanagari S. Vulimiri S, Mahadevan B. Genotoxicity biomarkers: Molecular basis of genetic variability and susceptibility. In: Biomarkers in Toxicology. Academic Press. 2014:729-742. https://doi.org/10.1016/B978-0-12-404630-6.00043-9
Borges S et al. Overview of the testing and assessment of effects of microbial pesticides on bees: strengths, challenges and perspectives. Apidologie. 2021:1-22.
Carvalho FP. Pesticides, environment, and food safety. Food and energy security. 2017;6(2):48-60. https://doi.org/10.1002/fes3.108
Cattelan MDP. et al. Occupational exposure to pesticides in family agriculture and the oxidative, biochemical and hematological profile in this agricultural model. Life Sci. 2018;15(203):177-183. https://doi.org/10.1016/j.lfs.2018.04.038
Costa C. et al. Influence of genetic polymorphism on pesticide-induced oxidative stress. Current Opinion in Toxicology. 2019;13:1-7. https://doi.org/10.1016/j.cotox.2018.12.008
Daenen K. et al. Oxidative stress in chronic kidney disease. Pediatr Nephrol. 2019;34(6):975-991. https://doi.org/10.1007/s00467-018-4005-4
Dalmolin SP et al. Biomarkers of occupational exposure to pesticides: Systematic review of insecticides. Environ Toxicol Pharmacol. 2020;75:103304. https://doi.org/10.1016/j.etap.2019.103304
Dhananjayan V, Jayakumar S, Ravichandran B. Conventional methods of pesticide application in agricultural field and fate of the pesticides in the environment and human health. In: Controlled release of pesticides for sustainable agriculture. Springer, Cham. 2020:1-39. https://doi.org/10.1007/978-3-030-23396-9_1
Dhananjayan V, Ravichandran B. Occupational health risk of farmers exposed to pesticides in agricultural activities. Current Opinion in Environmental Science & Health. 2018;4:31-37. https://doi.org/10.1016/j.coesh.2018.07.005
Esteban-López M et al. Selecting the best non-invasive matrix to measure mercury exposure in human biomonitoring surveys. Environ Res. 2022; 204(Pt D):112394.https://doi.org/10.1016/j.envres.2021.112394
Gangemi S et al. Occupational exposure to pesticides as a possible risk factor for the development of chronic diseases in humans (Review). Mol Med Rep. 2016;14(5):4475-4488. https://doi.org/10.3892/mmr.2016.5817
Garcia EIC et al., Dietary Supplements of Vitamins E, C, and β-Carotene to Reduce Oxidative Stress in Horses: An Overview. J Equine Vet Sci. 2022;110:103863. https://doi.org/10.1016/j.jevs.2022.103863
Gonçalves AMM et al. Enzymes as useful biomarkers to assess the response of freshwater communities to pesticide exposure–A review. Ecological Indicators. 2021;122:107303.https://doi.org/10.1016/j.ecolind.2020.107303
Groot MJ, Van’t Hooft KE. The hidden effects of dairy farming on public and environmental health in the Netherlands, India, Ethiopia, and Uganda, considering the use of antibiotics and other agro-chemicals. Frontiers in public health. 2016;4:12. https://doi.org/10.3389/fpubh.2016.00012
Gulcin İ. Antioxidants and antioxidant methods: An updated overview. Archives of toxicology. 2020;94(3):651-715. https://doi.org/10.1007/s00204-020-02689-3
Ighodaro OM, Akinloye OA. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria journal of medicine. 2018;54(4):287-293. https://doi.org/10.1016/j.ajme.2017.09.001
Jabłońska-Trypuć A. et al., The impact of pesticides on oxidative stress level in human organism and their activity as an endocrine disruptor. J Environ Sci Health B. 2017; 52(7):483-494. https://doi.org/10.1080/03601234.2017.1303322
Jayaraj R, Megha P, Sreedev P. Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment. Interdisciplinary Toxicology. 2016;9(3-4):90-100. https://doi.org/10.1515/intox-2016-0012
Kerfoot WC et al. Coastal Remote Sensing: Merging Physical, Chemical, and Biological Data as Tailings Drift onto Buffalo Reef, Lake Superior. Remote Sens. 2021;13(13):2434. https://doi.org/10.3390/rs13132434
Kokolakis S. Determination of Pesticide Residues in Orange Samples using Chromatographic Techniques coupled with High Resolution Mass Spectrometry. 2019. 169p. Master Thesis (Master Degree in Chemistry) - National and Kapodistrian University of Athens, Athens; 2019.
Lebov JF et al. Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study. Occup Environ Med. 2016;73(1):3-12. https://doi.org/10.1136/oemed-2014-102615
Ledda C et al. Oxidative stress and DNA damage in agricultural workers after exposure to pesticides. J Occup Med Toxicol. 2021;16(1):1. https://doi.org/10.1186/s12995-020-00290-z
Lee GH, Choi KC. Adverse effects of pesticides on the functions of immune system. Comp Biochem Physiol. Toxicol Pharmacol. 2020;235:108789. https://doi.org/10.1016/j.cbpc.2020.108789
Liguori I et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;26(13):757-772. https://doi.org/10.2147/CIA.S158513
Lozano-Paniagua D et al. Biomarkers of oxidative stress in blood of workers exposed to non-cholinesterase inhibiting pesticides. Ecotoxicol Environ Saf. 2018;162:121-128. https://doi.org/10.1016/j.ecoenv.2018.06.074
Machado SC, Martins I. Risk assessment of occupational pesticide exposure: Use of endpoints and surrogates. Regulatory Toxicology and Pharmacology. 2018;98:276-283. https://doi.org/10.1016/j.yrtph.2018.08.008
Maniaci A et al. Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients. J Clin Med. 2021;10(2):277. https://doi.org/10.3390/jcm10020277
Maurya P, Yadav L. Uses of pesticide in foods: Curse for health. Asian Journal of Bio Science. 2014;9(1):123–128.
Mcleish C Johnstone P, Schot J. The changing landscape of deep transitions: Sociotechnical imprinting and chemical warfare. Environmental Innovation and Societal Transitions. 2022;43:146-159. https://doi.org/10.1016/j.eist.2022.03.008
Mercado SAS, Caleño JDQ. Cytotoxic evaluation of glyphosate, using Allium cepa L. as bioindicator. Science of the total environment.2020;(700):134452. https://doi.org/10.1016/j.scitotenv.2019.134452
Nagy K, Tessema RA, Budnik LT. Ádám, B. Comparative cyto- and genotoxicity assessment of glyphosate and glyphosate-based herbicides in human peripheral white blood cells. Environ Res. 2019;179:108851. https://doi.org/10.1016/j.envres.2019.108851
Peluso I et al. Biomarkers of Oxidative Stress in Experimental Models and Human Studies with Nutraceuticals: Measurement, Interpretation, and Significance. Oxid Med Cell Longev. 2017;2016:6159810. https://doi.org/10.1155/2017/3457917
Radulescu C. et al. Correlação entre antioxidantes enzimáticos e não enzimáticos em várias espécies de cogumelos comestíveis. In: Engenharia de Alimentos. Londres: IntechOpen. 2019:1-31.
Raffa CM, Chiampo F. Bioremediation of agricultural soils polluted with pesticides: A review. Bioengineering. 2021; 8(7):92. https://doi.org/10.3390/bioengineering8070092
Rietjens IMCM. et al. Exposure assessment of process-related contaminants in food by biomarker monitoring. Arch Toxicol. 2018;92(1):15-40. https://doi.org/10.1007/s00204-017-2143-2
Rousis NI. et al., Wastewater-based epidemiology to assess pan-European pesticide exposure. Water Res. 2017;121:270-279. https://doi.org/10.1016/j.watres.2017.05.044
Rousis NZ, Uccato E, Castiglioni S. Monitoring population exposure to pesticides based on liquid chromatography-tandem mass spectrometry measurement of their urinary metabolites in urban wastewater: A novel biomonitoring approach. Science of the Total Environment. 2016;571:1349-1357.https://doi.org/10.1016/j.scitotenv.2016.07.036
Sabarwal A, Kumar K, Singh RP. Hazardous effects of chemical pesticides on human health-Cancer and other associated disorders. Environmental toxicology and pharmacology. 2018;63:103-114. https://doi.org/10.1016/j.etap.2018.08.018
Schaumburg LG et al. Genotoxicity induced by Roundup® (Glyphosate) in tegu lizard (Salvator merianae) embryos. Pestic Biochem Physiol. 2016;130:71-78. https://doi.org/10.1016/j.pestbp.2015.11.009
Sies H, Jones DP. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol. 2020;21(7):363-383.https://doi.org/10.1038/s41580-020-0230-3
Sule RO, Condon L, Gomes AV. A Common Feature of Pesticides: Oxidative Stress-The Role of Oxidative Stress in Pesticide-Induced Toxicity. Oxid Med Cell Longev. 2022;19(2022):5563759.https://doi.org/10.1155/2022/5563759
Sumudumali RGI, Jayawardana JMCK. A Review of Biological Monitoring of Aquatic Ecosystems Approaches: with Special Reference to Macroinvertebrates and Pesticide Pollution. Environ Manage. 2021;67(2):263-276. https://doi.org/10.1007/s00267-020-01423-0
Tarboush NA et al. Genotoxicity of Glyphosate on Cultured Human Lymphocytes. Int J Toxicol. 2022;41(2):126-131. https://doi.org/10.1177/10915818211073514
Thomine E, Mumford J, Rusch A, Desneux N. Using crop diversity to lower pesticide use: Socio-ecological approaches. Sci Total Environ. 2022;804:150156. https://doi.org/10.1016/j.scitotenv.2021.150156
Torres S et al. Biomarkers of Exposure to Secondhand and Thirdhand Tobacco Smoke: Recent Advances and Future Perspectives. Int J Environ Res Public Health. 2018;15(12):2693.https://doi.org/10.3390/ijerph15122693
Townsend M et al. Evaluation of various glyphosate concentrations on DNA damage in human Raji cells and its impact on cytotoxicity. Regul Toxicol Pharmacol. 2017;85:79-85. https://doi.org/10.1016/j.yrtph.2017.02.002
Wang L et al. Chlorpyrifos exposure in farmers and urban adults: Metabolic characteristic, exposure estimation, and potential effect of oxidative damage. Environ Res. 2016;149:164-170.https://doi.org/10.1016/j.envres.2016.05.011
Warra AA, Prasad MNV. African perspective of chemical usage in agriculture and horticulture - their impact on human health and environment. In: Agrochemicals Detection, Treatment and Remediation. Butterworth-Heinemann. 2020; 401-436. https://doi.org/10.1016/B978-0-08-103017-2.00016-7
Wigner P et al. Oxidative stress parameters as biomarkers of bladder cancer development and progression. Sci Rep. 11(1):15134, 2021. https://doi.org/10.1038/s41598-021-94729-w
Zingg JM. Vitamin E: regulatory role on signal transduction. IUBMB life. 2019;71(4):456-478. https://doi.org/10.1002/iub.1986
Zulaikhah ST. The role of antioxidant to prevent free radicals in the body. Sains Medika. 2017;8(1):39-45. https://doi.org/10.26532/sainsmed.v8i1.1012
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Copyright (c) 2023 Heberson Teixeira da Silva, Kimberly Silva Souza, Kaynara Trevisan, Dilceu Silveira Tolentino Júnior, Tales Alexandre Aversi-Ferreira
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