Efeitos ansiolíticos do Atenolol injetado no núcleo accumbens septi em ratos após restrição de estresse no teste do labirinto em cruz Elevado
DOI:
https://doi.org/10.61695/rcs.v1i1.8Palavras-chave:
Atenolol, Labirinto em cruz elevado, Glutamato, Accumbens, Ansiedade, EsquizofreniaResumo
Objetivos: Anteriormente, observamos que a injeção de antagonistas de glutamato injetados dentro do Nucleus Accumbens Septi (NAS) produziu um efeito ansiolítico no teste do labirinto em cruz elevado (LCE) em ratos em estado basal não perturbado. O efeito do metoprolol, um antagonista específico do receptor beta-1 adrenérgico no LCE, foi estudado anteriormente em condição de repouso em ratos machos canulados bilateralmente no NAS. Métodos: Os ratos foram previamente submetidos ao estresse de contenção e divididos em quatro grupos. Eles receberam injeções bilaterais de 1 μl de solução salina (n=13) ou atenolol em diferentes doses dentro do NAS: 0,75 (n=15), 1 (n=13) e 2 μg/1 μl (n=13), 15 min antes do teste. Os ratos foram mantidos sob controle entre a injeção e o teste. Resultados: O tempo gasto no braço aberto (TSOA) foi modificado pelo tratamento (F = 4,239, p = 0,0096, df = 3) e aumentado pelo grupo de dose média quando comparado com o grupo de solução salina (p<0,05) e o grupo de dose média e grupo de dose mais baixa (p<0,01). As entradas de braços abertos (EOA) foram modificadas pelo tratamento (F = 3,461, p = 0,0231, gl = 3). Esse parâmetro foi aumentado pela dose média de atenolol (p<0,05) quando comparado ao soro fisiológico e à dose mais baixa. Não foram observadas diferenças significativas nos demais parâmetros estudados. Conclusão: Concluímos que o bloqueio do receptor beta-1 pelo atenolol dentro do NAS após a contenção leva a um efeito do tipo ansiolítico relacionado ao aumento do Tempo Passado no Braço Aberto (TSOA), e à desinibição comportamental, evidenciada no aumento de Entradas de Braço Aberto (EOA), mostrando um padrão comportamental específico.
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Copyright (c) 2023 Luis Hernán Llano López, Miriam Fraile, Adriana Inés Landa, Norman Darío López Velásquez, Manuel Alejandro Guevara, José Vicente Lafuente Sánchez, Pascual Ángel Gargiulo
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